diff --git a/.github/workflows/run_tests.yml b/.github/workflows/run_tests.yml
new file mode 100644
index 0000000..9badd79
--- /dev/null
+++ b/.github/workflows/run_tests.yml
@@ -0,0 +1,27 @@
+name: Test JSON Manifests
+
+on:
+  pull_request:
+    types: [opened, synchronize, reopened, review_requested, edited, closed]
+  push:
+    branches: [main]
+
+jobs:
+  build:
+    runs-on: ubuntu-latest
+    strategy:
+      matrix:
+        python-version: ["3.9"]
+    steps:
+      - uses: actions/checkout@v3
+      - name: Set up Python ${{ matrix.python-version }}
+        uses: actions/setup-python@v4
+        with:
+          python-version: ${{ matrix.python-version }}
+      - name: Install dependencies
+        run: |
+          python -m pip install --upgrade pip
+          python -m pip install .
+      - name: Run tests
+        run: |
+          python -m pytest -v -s tests/
\ No newline at end of file
diff --git a/.gitignore b/.gitignore
index df3131b..368974a 100644
--- a/.gitignore
+++ b/.gitignore
@@ -1 +1,57 @@
-# Add local config files / secrets here to ignore them when you commit.
+# Byte-compiled / optimized / DLL files
+__pycache__/
+*.py[cod]
+*$py.class
+
+# C extensions
+*.so
+
+# Distribution / packaging
+.Python
+build/
+develop-eggs/
+dist/
+downloads/
+eggs/
+.eggs/
+lib/
+lib64/
+parts/
+sdist/
+var/
+wheels/
+share/python-wheels/
+*.egg-info/
+.installed.cfg
+*.egg
+MANIFEST
+
+# PyInstaller
+#  Usually these files are written by a python script from a template
+#  before PyInstaller builds the exe, so as to inject date/other infos into it.
+*.manifest
+*.spec
+
+# Installer logs
+pip-log.txt
+pip-delete-this-directory.txt
+
+# Unit test / coverage reports
+htmlcov/
+.tox/
+.nox/
+.coverage
+.coverage.*
+.cache
+nosetests.xml
+coverage.xml
+*.cover
+*.py,cover
+.hypothesis/
+.pytest_cache/
+cover/
+
+# Sphinx documentation
+docs/_build/
+
+.DS_Store
\ No newline at end of file
diff --git a/aiod_registry/__init__.py b/aiod_registry/__init__.py
new file mode 100644
index 0000000..45e0670
--- /dev/null
+++ b/aiod_registry/__init__.py
@@ -0,0 +1 @@
+from aiod_registry.schema import ModelManifest
diff --git a/aiod_registry/manifests/mitonet.json b/aiod_registry/manifests/mitonet.json
new file mode 100644
index 0000000..f2ce70f
--- /dev/null
+++ b/aiod_registry/manifests/mitonet.json
@@ -0,0 +1,71 @@
+{
+    "name": "Mitonet",
+    "versions": [
+      {
+        "name": "MitoNet v1",
+        "tasks": [
+          {
+            "task": "mito",
+            "location": "https://zenodo.org/record/6861565/files/MitoNet_v1.pth?download=1"
+          }
+        ]
+      },
+      {
+        "name": "MitoNet Mini v1",
+        "tasks": [
+          {
+            "task": "mito",
+            "location": "https://zenodo.org/record/6861565/files/MitoNet_v1_mini.pth?download=1"
+          }
+        ]
+      }
+    ],
+    "params": [
+    {
+        "name": "Plane",
+        "value": ["XY", "XZ", "YZ", "All"],
+        "tooltip": "Whether to use all planes (XY, XZ, YZ) or a single plane"
+    },
+    {
+        "name": "Downsampling",
+        "value": [1, 2, 4, 8, 16, 32, 64],
+        "tooltip": "Downsampling factor for the input image"
+    },
+    {
+        "name": "Segmentation threshold",
+        "short_name": "conf_threshold",
+        "value": 0.5,
+        "tooltip": "Confidence threshold for the segmentation"
+    },
+    {
+        "name": "Center threshold",
+        "short_name": "center_threshold",
+        "value": 0.1,
+        "tooltip": "Confidence threshold for the center"
+    },
+    {
+        "name": "Minimum distance",
+        "short_name": "min_distance",
+        "value": 3,
+        "tooltip": "Minimum distance between object centers"
+    },
+    {
+        "name": "Maximum objects",
+        "short_name": "max_objects",
+        "value": 1000,
+        "tooltip": "Maximum number of objects to segment per class"
+    },
+    {
+        "name": "Semantic only",
+        "short_name": "semantic_only",
+        "value": false,
+        "tooltip": "Only run semantic segmentation for all classes"
+    },
+    {
+        "name": "Fine boundaries",
+        "short_name": "fine_boundaries",
+        "value": false,
+        "tooltip": "Finer boundaries between objects"
+    }
+    ]
+  }
\ No newline at end of file
diff --git a/aiod_registry/manifests/sam_test.json b/aiod_registry/manifests/sam_test.json
new file mode 100644
index 0000000..967a07c
--- /dev/null
+++ b/aiod_registry/manifests/sam_test.json
@@ -0,0 +1,124 @@
+{
+  "name": "Segment Anything",
+  "short_name": "sam",
+  "versions": [
+    {
+      "name": "default",
+      "tasks": [
+        {
+          "task": "everything",
+          "location": "https://dl.fbaipublicfiles.com/segment_anything/sam_vit_h_4b8939.pth",
+          "config_path": null
+        }
+      ]
+    },
+    {
+      "name": "vit_h",
+      "tasks": [
+        {
+          "task": "everything",
+          "location": "https://dl.fbaipublicfiles.com/segment_anything/sam_vit_h_4b8939.pth",
+          "config_path": null
+        }
+      ]
+    },
+    {
+      "name": "vit_l",
+      "tasks": [
+        {
+          "task": "everything",
+          "location": "https://dl.fbaipublicfiles.com/segment_anything/sam_vit_l_0b3195.pth",
+          "config_path": null
+        }
+      ]
+    },
+    {
+      "name": "vit_b",
+      "tasks": [
+        {
+          "task": "Mito",
+          "location":"https://dl.fbaipublicfiles.com/segment_anything/sam_vit_b_01ec64.pth",
+          "config_path": null
+        }
+      ]
+    },
+    {
+      "name": "MedSAM",
+      "tasks": [
+        {
+          "task": "everything",
+          "location": "https://syncandshare.desy.de/index.php/s/yLfdFbpfEGSHJWY/download/medsam_20230423_vit_b_0.0.1.pth",
+          "config_path": null
+        }
+      ]
+    }
+  ],
+  "params": [
+    {
+        "name": "Points per side",
+        "short_name": "points_per_side",
+        "value": 32,
+        "tooltip": ""
+    },
+    {
+        "name": "Points per batch",
+        "short_name": "points_per_batch",
+        "value": 64,
+        "tooltip": ""
+    },
+    {
+        "name": "Pred IoU threshold",
+        "short_name": "pred_iou_thresh",
+        "value": 0.88,
+        "tooltip": ""
+    },
+    {
+        "name": "Stability score threshold",
+        "short_name": "stability_score_thresh",
+        "value": 0.95,
+        "tooltip": ""
+    },
+    {
+        "name": "Stability score offset",
+        "short_name": "stability_score_offset",
+        "value": 1,
+        "tooltip": ""
+    },
+    {
+        "name": "Box nms_thresh",
+        "short_name": "box_nms_thresh",
+        "value": 0.7,
+        "tooltip": ""
+    },
+    {
+        "name": "Crop N layers",
+        "short_name": "crop_n_layers",
+        "value": 0,
+        "tooltip": ""
+    },
+    {
+        "name": "Crop NMS thresh",
+        "short_name": "crop_nms_thresh",
+        "value": 0.7,
+        "tooltip": ""
+    },
+    {
+        "name": "Crop overlap ratio",
+        "short_name": "crop_overlap_ratio",
+        "value": 0.34133,
+        "tooltip": ""
+    },
+    {
+        "name": "Crop B points downscale factor",
+        "short_name": "crop_n_points_downscale_factor",
+        "value": 0.5,
+        "tooltip": ""
+    },
+    {
+        "name": "Min mask region area",
+        "short_name": "min_mask_region_area",
+        "value": 3,
+        "tooltip": ""
+    }
+  ]
+}
\ No newline at end of file
diff --git a/aiod_registry/manifests/unet_seai.json b/aiod_registry/manifests/unet_seai.json
new file mode 100644
index 0000000..8de2444
--- /dev/null
+++ b/aiod_registry/manifests/unet_seai.json
@@ -0,0 +1,31 @@
+{
+  "name": "SEAI U-Net",
+  "short_name": "seai_unet",
+  "versions": [
+    {
+      "name": "U-Net",
+      "tasks": [
+        {
+          "task": "mito",
+          "location": "/nemo/stp/ddt/working/shandc/aiod_models/mito_5nm_intensity_augs_warp.best.969.pt",
+          "config_path": "/nemo/stp/ddt/working/shandc/aiod_models/mito_5nm_intensity_augs_warp.yml"
+        }
+      ]
+    },
+    {
+      "name": "Attention U-Net",
+      "tasks": [
+        {
+          "task": "mito",
+          "location": "/nemo/stp/ddt/working/shandc/aiod_models/Attention_HUNet_3e5_Adam_restart_12_16.best.1266.pt",
+          "config_path": "/nemo/stp/ddt/working/shandc/aiod_models/Attention_HUNet_3e5_Adam_restart_12_16.yml"
+        },
+        {
+          "task": "ne",
+          "location": "/nemo/stp/ddt/working/shandc/aiod_models/Attention_HUNet_NE.best.368.pt",
+          "config_path": "/nemo/stp/ddt/working/shandc/aiod_models/Attention_HUNet_NE.yml"
+        }
+      ]
+    }
+  ]
+}
\ No newline at end of file
diff --git a/aiod_registry/schema.py b/aiod_registry/schema.py
new file mode 100644
index 0000000..c03578a
--- /dev/null
+++ b/aiod_registry/schema.py
@@ -0,0 +1,55 @@
+import json
+from pathlib import Path
+from typing import Optional, Union
+
+from pydantic import BaseModel, ConfigDict, Field, model_validator, AnyUrl
+
+
+def shorten_name(name: str) -> str:
+    return "_".join(name.lower().split(" "))
+
+
+class StrictModel(BaseModel):
+    model_config = ConfigDict(extra="forbid")
+
+
+class ModelVersionTask(StrictModel):
+    # Regex pattern to match task names, ignoring case
+    task: str = Field(..., pattern=r"^(?i:mito|er|ne|everything)$")
+    location: Union[Path, AnyUrl, str] = Field(
+        ...,
+        description="Either a url or a filepath (will be skipped if the path does not exist/cannot be read)",
+    )
+    config_path: Optional[Union[Path, str]] = None
+
+
+class ModelVersion(StrictModel):
+    name: str = Field(..., min_length=1, max_length=50)
+    tasks: list[ModelVersionTask]
+
+
+class ModelParam(StrictModel):
+    name: str = Field(..., min_length=1, max_length=50)
+    short_name: Optional[str] = None
+    value: Union[str, int, float, bool, list[Union[str, int, float, bool]]]
+    tooltip: Optional[str] = None
+
+    @model_validator(mode="after")
+    def create_short_name(self):
+        if self.short_name is None:
+            self.short_name = shorten_name(self.name)
+        return self
+
+
+class ModelManifest(StrictModel):
+    name: str = Field(..., min_length=1, max_length=50)
+    short_name: Optional[str] = None
+    versions: list[ModelVersion]
+    params: Optional[list[ModelParam]] = None
+    config: Optional[Path] = None
+
+    @model_validator(mode="after")
+    def create_short_name(self):
+        if self.short_name is None:
+            self.short_name = shorten_name(self.name)
+        return self
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..bfb3aeb
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,23 @@
+[build-system]
+build-backend = 'setuptools.build_meta'
+requires = [
+    'setuptools>=61.0.0',
+]
+
+[project]
+name = "aiod-registry"
+description = "A registry of models for use with AI OnDemand (AIoD)"
+version = "0.0.1"
+authors = [
+    {name = "Cameron Shand", email = "cameron.shand@crick.ac.uk"},
+    {name = "Jon Smith", email = "jon.smith@crick.ac.uk"}
+]
+dependencies = [
+    "pytest",
+    "pydantic >= 2.0"
+]
+requires-python = ">=3.9"
+dynamic = ["readme"]
+
+[tool.setuptools.dynamic]
+readme = {file = ["README.md"], content-type = "text/markdown"}
\ No newline at end of file
diff --git a/tests/test_jsons.py b/tests/test_jsons.py
new file mode 100644
index 0000000..a4be928
--- /dev/null
+++ b/tests/test_jsons.py
@@ -0,0 +1,23 @@
+import json
+from pathlib import Path
+
+from pydantic import ValidationError
+import pytest
+
+from aiod_registry import ModelManifest
+
+
+def get_jsons():
+    json_dir = Path(__file__).parent.parent / "aiod_registry" / "manifests"
+    print(json_dir)
+    return json_dir.glob("*.json")
+
+
+@pytest.mark.parametrize("json_path", get_jsons())
+def test_manifest(json_path):
+    with open(json_path, "r") as f:
+        json_manifest = json.load(f)
+        try:
+            ModelManifest.model_validate(json_manifest)
+        except ValidationError as e:
+            raise e