diff --git a/.github/workflows/test-software.eessi.io.yml b/.github/workflows/test-software.eessi.io.yml
index e247c96676..6f592cf4c4 100644
--- a/.github/workflows/test-software.eessi.io.yml
+++ b/.github/workflows/test-software.eessi.io.yml
@@ -27,6 +27,7 @@ jobs:
         - aarch64/neoverse_v1
         - x86_64/amd/zen2
         - x86_64/amd/zen3
+        - x86_64/amd/zen4
         - x86_64/intel/haswell
         - x86_64/intel/skylake_avx512
         - x86_64/generic
@@ -58,6 +59,15 @@ jobs:
               # first check the CPU-only builds for this CPU target
               echo "just run check_missing_installations.sh (should use easystacks/software.eessi.io/${{matrix.EESSI_VERSION}}/eessi-${{matrix.EESSI_VERSION}}-*.yml)"
               for easystack_file in $(ls easystacks/software.eessi.io/${{matrix.EESSI_VERSION}}/eessi-${{matrix.EESSI_VERSION}}-eb-*.yml); do
+                  if [ ${{matrix.EESSI_SOFTWARE_SUBDIR_OVERRIDE}} = "x86_64/amd/zen4" ]; then
+                      if grep -q 2022b <<<"${easystack_file}"; then
+                          # skip the check of installed software on zen4 for foss/2022b builds
+                          continue
+                      elif grep -q CUDA <<<"${easystack_file}"; then
+                          # skip the check of install CUDA software in the CPU path for zen4
+                          continue
+                      fi
+                  fi
                   echo "check missing installations for ${easystack_file}..."
                   ./check_missing_installations.sh ${easystack_file}
                   ec=$?