diff --git a/.github/workflows/build-and-publish-bootstrap-container.yml b/.github/workflows/build-and-publish-bootstrap-container.yml
new file mode 100644
index 00000000..fba12a72
--- /dev/null
+++ b/.github/workflows/build-and-publish-bootstrap-container.yml
@@ -0,0 +1,52 @@
+name: Build and publish EESSI Docker image for bootstrapping Gentoo Prefix
+on:
+  push:
+    branches:
+      - main
+    paths:
+      - Dockerfile.bootstrap-prefix-centos8
+      - bootstrap-prefix.sh
+
+  pull_request:
+    branches:
+      - main
+    paths:
+      - Dockerfile.bootstrap-prefix-centos8
+      - bootstrap-prefix.sh
+ 
+jobs:
+  build_and_publish:
+    name: Build and publish image
+    runs-on: ubuntu-latest
+    permissions:
+      packages: write
+      contents: read
+    steps:
+      - name: Check out the repo
+        uses: actions/checkout@v2
+
+      - name: Set up QEMU
+        uses: docker/setup-qemu-action@v1
+
+      - name: Set up Docker Buildx
+        uses: docker/setup-buildx-action@v1
+
+      - name: Login to GitHub Container Registry
+        if: github.event_name != 'pull_request'
+        uses: docker/login-action@v1 
+        with:
+          registry: ghcr.io
+          username: ${{ github.repository_owner }}
+          password: ${{ secrets.GITHUB_TOKEN }}
+
+      - name: Convert and store repository owner in lowercase
+        run: |
+          echo "REPOSITORY_OWNER=$(echo ${{ github.repository_owner }} | tr '[:upper:]' '[:lower:]')" >> $GITHUB_ENV
+
+      - name: Build and push to GitHub Packages
+        uses: docker/build-push-action@v2
+        with:
+          tags: ghcr.io/${{ env.REPOSITORY_OWNER }}/bootstrap-prefix:centos8
+          file: Dockerfile.bootstrap-prefix-centos8
+          platforms: linux/amd64, linux/arm64, linux/ppc64le
+          push: ${{ github.event_name != 'pull_request' }}
diff --git a/Dockerfile.bootstrap-prefix-centos8-aarch64 b/Dockerfile.bootstrap-prefix-centos8
similarity index 87%
rename from Dockerfile.bootstrap-prefix-centos8-aarch64
rename to Dockerfile.bootstrap-prefix-centos8
index 0de29ba0..042794d2 100644
--- a/Dockerfile.bootstrap-prefix-centos8-aarch64
+++ b/Dockerfile.bootstrap-prefix-centos8
@@ -1,4 +1,4 @@
-FROM docker.io/arm64v8/centos:8.2.2004
+FROM centos:8.2.2004
 
 COPY bootstrap-prefix.sh /usr/local/bin/bootstrap-prefix.sh
 
diff --git a/Dockerfile.bootstrap-prefix-centos8-ppc64le b/Dockerfile.bootstrap-prefix-centos8-ppc64le
deleted file mode 100644
index 63a87c94..00000000
--- a/Dockerfile.bootstrap-prefix-centos8-ppc64le
+++ /dev/null
@@ -1,11 +0,0 @@
-FROM docker.io/ppc64le/centos:8.2.2004
-
-COPY bootstrap-prefix.sh /usr/local/bin/bootstrap-prefix.sh
-
-RUN dnf install -y gcc gcc-c++ make diffutils gmp-devel
-RUN chmod 755 /usr/local/bin/bootstrap-prefix.sh
-
-ENV LC_ALL=C
-ENV PATH=/usr/local/bin:$PATH
-
-ENTRYPOINT ["/usr/local/bin/bootstrap-prefix.sh"]
diff --git a/Dockerfile.bootstrap-prefix-centos8-x86_64 b/Dockerfile.bootstrap-prefix-centos8-x86_64
deleted file mode 100644
index 3291de8b..00000000
--- a/Dockerfile.bootstrap-prefix-centos8-x86_64
+++ /dev/null
@@ -1,11 +0,0 @@
-FROM docker.io/library/centos:8.2.2004
-
-COPY bootstrap-prefix.sh /usr/local/bin/bootstrap-prefix.sh
-
-RUN dnf install -y gcc gcc-c++ make diffutils gmp-devel
-RUN chmod 755 /usr/local/bin/bootstrap-prefix.sh
-
-ENV LC_ALL=C
-ENV PATH=/usr/local/bin:$PATH
-
-ENTRYPOINT ["/usr/local/bin/bootstrap-prefix.sh"]
diff --git a/ansible/playbooks/roles/compatibility_layer/defaults/main.yml b/ansible/playbooks/roles/compatibility_layer/defaults/main.yml
index 8f648b36..a5bd0895 100644
--- a/ansible/playbooks/roles/compatibility_layer/defaults/main.yml
+++ b/ansible/playbooks/roles/compatibility_layer/defaults/main.yml
@@ -22,7 +22,7 @@ prefix_snapshot_version: 20210607
 prefix_user_defined_trusted_dirs:
   - "/cvmfs/{{ cvmfs_repository }}/host_injections/{{ eessi_version }}/compat/{{ eessi_host_os }}/{{ eessi_host_arch }}/lib"
 prefix_singularity_command: "singularity run -B {{ gentoo_prefix_path }}:{{ gentoo_prefix_path }}"
-prefix_source: "docker://eessi/bootstrap-prefix:centos8-{{ eessi_host_arch }}"
+prefix_source: "docker://ghcr.io/eessi/bootstrap-prefix:centos8"
 prefix_source_options: "{{ gentoo_prefix_path }} noninteractive"
 prefix_install: >-
     SINGULARITYENV_USE_CPU_CORES={{ ansible_processor_vcpus }}
diff --git a/docker_build_bootstrap_prefix.sh b/docker_build_bootstrap_prefix.sh
deleted file mode 100755
index 2da0d370..00000000
--- a/docker_build_bootstrap_prefix.sh
+++ /dev/null
@@ -1,10 +0,0 @@
-#!/bin/bash
-
-cpu_arch=$(uname -m)
-tag="eessi/bootstrap-prefix:centos8-${cpu_arch}"
-
-echo "Building EESSI container for bootstrapping Prefix on ${cpu_arch}..."
-docker build --no-cache -f Dockerfile.bootstrap-prefix-centos8-${cpu_arch} -t ${tag} .
-
-echo "Pushing ${tag} to Docker Hub..."
-docker push ${tag}
diff --git a/singularity-bootstrap-prefix.arm64v8.def b/singularity-bootstrap-prefix.arm64v8.def
deleted file mode 100644
index df091a5f..00000000
--- a/singularity-bootstrap-prefix.arm64v8.def
+++ /dev/null
@@ -1,16 +0,0 @@
-Bootstrap: docker
-From: arm64v8/centos:8.2.2004
-
-%post
-    dnf install -y gcc gcc-c++ make diffutils gmp-devel
-    chmod 755 /usr/local/bin/bootstrap-prefix.sh
-
-%environment
-    export LC_ALL=C
-    export PATH=/usr/local/bin:$PATH
-
-%files
-    bootstrap-prefix.sh /usr/local/bin
-
-%runscript
-    exec /usr/local/bin/bootstrap-prefix.sh "$@"
diff --git a/singularity-bootstrap-prefix.def b/singularity-bootstrap-prefix.def
deleted file mode 100644
index e9c4cf8e..00000000
--- a/singularity-bootstrap-prefix.def
+++ /dev/null
@@ -1,16 +0,0 @@
-Bootstrap: docker
-From: centos:8.2.2004
-
-%post
-    dnf install -y gcc gcc-c++ make diffutils
-    chmod 755 /usr/local/bin/bootstrap-prefix.sh
-
-%environment
-    export LC_ALL=C
-    export PATH=/usr/local/bin:$PATH
-
-%files
-    bootstrap-prefix.sh /usr/local/bin
-
-%runscript
-    exec /usr/local/bin/bootstrap-prefix.sh "$@"