eeDAP is a software and hardware platform for designing and executing digital and analog pathology studies where evaluation regions of interest (ROIs) in the digital image are registered to the real-time view on the microscope. This registration allows for the reduction or elimination of a large source of variability in comparing these modalities in the hands of the pathologist: the field of view (the tissue) being evaluated. In fact, the current registration precision of eeDAP allows for the presentation of the same individual cell in both domains. As such, a study can be designed where pathologists are asked to evaluate a pre-selected list of individual cells in Digital mode and Microscope real-time mode (MicroRT mode). eeDAP collects the pathologist evaluations while cycling through the list of cells. In Digital mode, the pathologist can enter the evaluations himself or herself. In MicroRT mode, an administrator enters the evaluations while confirming and maintaining a high level of registration precision. The paired observations allow for comparisons of WSI and traditional optical microscopy using several forms of agreement or performance when a reference standard can be established.
Gallas, Brandon D., Marios A. Gavrielides, Catherine Conway, Adam Ivansky, Tyler Keay, Wei-Chung Cheng, Jason Hipp, and Stephen M. Hewitt. “Evaluation Environment for Digital and Analog Pathology (EeDAP): A Platform for Validation Studies.” J Med Img 1 (2014): 037501. https://doi.org/10.1117/1.JMI.1.3.037501.
Q. Gong, B. P. Berman, M. A. Gavrielides, and B. D. Gallas, “Registration accuracy between whole slide images and glass slides in eeDAP workflow,” in Medical imaging 2018: digital pathology, 2018, vol. 10581. https://doi.org/10.1117/12.2293189
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Here are demo videos for running eeDAP in digital mode and microRT mode.
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We hope you are interested in trying our software. Please know that we are willing to help you in many ways: set-up of hardware, modifying the tasks for your application, and even the design and execution of your study. Of course, help with the design and execution of a study depends on our capacity and alignment with our mission.
Similarly we hope you will provide feedback on the software and documentation so that we can make this project the best it can be.
Please check out a statement of the licenses related to our software here.
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This list includes appropriate means by which you can reference our work.
