Server fails to respond while the client continues to function (Singleplayer)

[Dilnu]

Describe the bug
To the best of my understanding, the bug is an issue with the 'server' portion of the Minecraft client. Console commands, breaking blocks and

To Reproduce [Optional]
I encountered this behavior twice after fully automating metal alchemy. (Redstone and a water centrifuge into infinite of all metals.)

Components added for automated alchemy:
Two redstone master axis
Several reaction chambers
At least one fluid injector
Several limiter conduits
Salt reactor
Circuit plate set to timer mode
Circuit plate set to addition
auto crafters
Hopper filters
limiter conduits
glass pump

Components previously present in my base without issues:
Other types of circuit plates
Beam Reflector
Arcane extractor
Beam Siphon
Water centrifuge
Item Shifter
industrial crucible
fluid cooling chamber
heat cables
fluid pipes

Present in one failure but not the other:
Resonating filter
thermal conduit

Additional context [Optional]
Logs included here.

[Da-Technomancer]

I've not been able to reproduce this on my own, or determine the precise cause.
If you've still got a copy of the save file with this issue and are willing to send it to me, please let me know.