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ANTs Ecosystem Overview: Toward Practical, Integrative Pattern Theory

Overall goal of ANTs Ecosystem: Enable interpretable, visualizable mapping of high-dimensional spaces, starting with images but extending to modalities such as psychometric, genetics, clinical measurements, etc.

  • we will build towards this goal by demonstrating examples that build incrementally on each other

Schedule

Brief introductory material showcasing R and Python wrapping of ANTs functionality.

9:15 - 10: Special Intro to ANTs (for ICERM grads and postdocs)

these will evolve as our tutorial material matures.

10:30 - 12: Intro to ANTs for Medical Imaging

  • Theoretical framework: "Integrative pattern theory"

  • Discussion: Definition of images (physical space, transformation groups, pairwise mapping, groupwise mapping, etc.)

  • Discussion and working examples:

    • mapping biomedical images for statistical analysis and quantification: image registration

    • labeling biomedical images for statistical analysis and quantification: image segmentation

    • template construction: toward statistical representations of image populations

    • joint label fusion for anatomical labeling

    • functional MRI quantification - time permitting https://github.com/stnava/structuralFunctionalJointRegistration

12 - 1:30: Lunch

1:30 - 3: Deep Learning and Statistical Approaches in Medical Imaging

  • Discussion: Overview of ANTsRNet a collection of deep learning tools for biomedical image quantification

    • Tensorflow + Keras

    • pre-trained networks

  • Discussion and working examples:

    • U-net segmentation with template-based augmentation

      • brain extraction

      • brain segmentation (whole image, patch-based)

      • tumor segmentation

    • Deep learning-based regression

      • super-resolution

      • Res-nets and other architectures

      • integrative brain mapping with deep learning as a tool

  • Other possible topics (time permitting)

    • clustering

    • activation maps

    • deep feature maps

3:30 - 4:30: "Ask us about…” audience-motivated discussion of other topics

  • Possible topics:

    • neuroimaging modalities: DTI, PET, ASL, BOLD fMRI, microscopy

    • non-human primate and other animal studies

    • other organs: lungs, heart

    • population variability: baby brains, neurodegeneration, stroke/lesions, etc.

    • integration of imaging, genetics, psychometrics, socioeconomic status etc.

    • role of these tools in industry as applications, scientific tools in treatment of disease, etc.